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Abstract:

Objective: The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF.

Background: Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and/or maintenance of hyperexcitability of central neurons in pain, it was hypothesized that the levels of this neurotrophic factor may be modified by the application of therapeutic interventions, favoring a reduction in pain intensity.

Methods: A literature search of multiple electronic databases (Pubmed, PsycINFO, Medline (Ebsco), Scopus, WOS, Embase) was conducted to identify randomized control trials (RCTs) published without language restrictions up to and including March 2022. The search strategy was based on the combination of medical terms (Mesh) and keywords relating to the following concepts: “pain”, “chronic pain”, “brain derived neurotrophic factor”, “BDNF”, “physiotherapy”, and “physical therapy”. A total of seven papers were included. 

Results: There were two studies that showed statistically significant differences in pain intensity reduction and an increase in the BDNF levels that used therapies such as rTMS and EIMS in patients with chronic myofascial pain. However, the same conclusions cannot be drawn for the other physical therapies applied.

Conclusions: rTMS and EIMS interventions achieved greater short-term reductions in pain intensity and increased BDNF over other types of interventions in chronic myofascial pain patients, as demonstrated by a moderate amount of evidence. In contrast, other types of physical therapy (PT) interventions did not appear to be more effective in decreasing pain intensity and increasing BDNF levels than placebo PT or minimal intervention, as a low amount of evidence was found.

  1. Del Cura-González, I., Ariza-Cardiel, G., Polentinos-Castro, E., López-Rodríguez, J. A., Sanz-Cuesta, T., Barrio-Cortes, J., Andreu-Ivorra, B., Rodríguez-Barrientos, R., Ávila-Tomas, J. F., Gallego-Ruiz-de-Elvira, E., Lozano-Hernández, C., Martín-Fernández, J., & Educaguia Group (2022). Effectiveness of a game-based educational strategy e-EDUCAGUIA for implementing antimicrobial clinical practice guidelines in family medicine residents in Spain: a randomized clinical trial by cluster. BMC medical education, 22(1), 893. https://doi.org/10.1186/s12909-022-03843-4
  2. Ferrer-Peña, R., Cuenca-Martínez, F., Romero-Palau, M., Flores-Román, L. M., Arce-Vázquez, P., Varangot-Reille, C., & Suso-Martí, L. (2021). Effects of motor imagery on strength, range of motion, physical function, and pain intensity in patients with total knee arthroplasty: A systematic review and meta-analysis. Brazilian journal of physical therapy, 25(6), 698–708. https://doi.org/10.1016/j.bjpt.2021.11.001
  3. Serrano, J. I., Muñoz-García, D., Ferrer-Peña, R., D’eudeville, V., Brero, M., Boisson, M., & Del Castillo, M. D. (2020). Prior cortical activity differences during an action observation plus motor imagery task related to motor adaptation performance of a coordinated multi-limb complex task. Cognitive neurodynamics, 14(6), 769–779. https://doi.org/10.1007/s11571-020-09633-2
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Grupos de Investigación

El grupo Motion in Brains de Ciencias del Movimiento, Bioconducta y Estudio del Dolor forma parte del Instituto de Neurociencias y Ciencias del Movimiento (INCIMOV) del CSEU La Salle. 

Las lineas de investigación que desarrollo en este grupo tienen relación con: 

  • Procesos cognitivos implicados en los tratamientos de fisioterapia aplicados al paciente con dolor

  • Factores bioconductuales implicados en el dolor crónico

  • El efecto de la educación terapéutica sobre los pacientes con dolor crónico

  • Entrenamiento cerebral y sus implicaciones clínicas sobre la actividad motora y sensorial

El Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ) está acreditado por el Instituto de Salud Carlos III (ISCIII). En este grupo desarrollo mi actividad científica en el Grupo 2, del Área de Neurociencias, sobre NEUROLOGÍA Y ENFERMEDADES CEREBROVASCULARES.

Las líneas de investigación que desarrollo en este grupo son las relacionadas con:

  • Enfermedades Neurodegenerativas
  • Cefaleas y dolor neuropático